Occupational and Environmental Medicine 1995;52:621-624 Fibrogenic effect of woliastonite compared with asbestos dust and dusts

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a day, 5 days a week for 12 months plus 12 months observation, or for a full 24 months) inhalation exposure of wollastonite in rats (McConnell et al, 1991), I was surprised to find the authors of this article reporting pulmonary fibrosis after intratracheal (IT) instillation. I offer the following comments and possible explanation for this unexpected result. It is difficult to determine from the report what their rats were actually exposed to or the total exposure. The authors reported that they obtained their wollastonite sample by "mechanical treatment (crushing, sedimentation, etc)" and reported a geometric

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Occupational and Environmental Medicine 1995;52:621-624 Fibrogenic effect of woliastonite compared with asbestos dust and dusts

a day, 5 days a week for 12 months plus 12 months observation, or for a full 24 months) inhalation exposure of wollastonite in rats (McConnell et al, 1991), I was surprised to find the authors of this article reporting pulmonary fibrosis after intratracheal (IT) instillation. I offer the following comments and possible explanation for this unexpected result. It is difficult to determine from th...

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Fibrogenic effect of wollastonite compared with asbestos dust and dusts containing quartz.

The distribution of length and diameter and the aspect ratio of crocidolite asbestos, a mineral substitute for asbestos (wollastonite), a manmade mineral fibre (glass wool), and synthetic fibres (polypropylene and polyacrylonitrite) were determined by light microscopy with phase contrast and, for crocidolite, also with transmission electron microscopy. The synthetic organic fibres and manmade m...

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Airway wall remodeling induced by occupational mineral dusts and air pollutant particles.

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Exposure to mineral dusts is associated with the development of chronic airflow obstruction, probably mediated in part by dust-induced fibrosis of the small airways. To investigate the mechanism of fibrosis, we exposed rat tracheal explants to amosite asbestos, iron oxide, or titanium dioxide. Explants were then maintained in air organ culture, and the expression of genes encoding for various m...

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The mode of action of inorganic fibers as carcinogens is unknown. There is conflicting evidence whether they act by inducing lesions in DNA, such as initiating carcinogens, or alternatively act as promoters of carcinogenesis. Recent evidence has suggested that promoters inhibit the process of cell-to-cell chemical communication known as metabolic cooperation. Chinese hamster V79-4 cells in cult...

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تاریخ انتشار 2005